phenobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. CYP3A4 inducers may perhaps increase the metabolism of ifosfamide to its Energetic alkylating metabolites.Keep an eye on Closely (one)somatropin will reduce the extent or impact of phenobarbital by influencing hepa